In 1976, Basinger decided to take a more serious stab at acting, and moved to Los Angeles. Within a year, she made her television debut as a female police detective in the pilot for a short-lived crime drama entitled Dog and Cat; in 1978, she landed the starring role in the made-for-TV movie Katie: Portrait of a Centerfold, appropriately playing a beautiful Southern girl who comes to Los Angeles in search of stardom. After being cast as Lorene Rogers in a TV remake of From Here to Eternity (a role she reprised in a subsequent series based upon the film), Basinger finally made her way to the big screen in the low-budget drama Hard Country. But while it (and Basinger) received good reviews, her screen career didn't take off in a big way until 1983, when she was cast opposite Sean Connery in the James Bond adventure Never Say Never Again. She also posed for a well-publicized layout in Playboy which, coinciding with the film's release, certainly didn't hurt her growing popularity.

While Basinger's career took off after Never Say Never Again, and she appeared in several major hits (including The Natural, 9 1/2 Weeks, and Batman, the latter of which led to a brief romance with pop star Prince), quality roles tended to elude her. But she generally fared well with the material given to her, and shined in several smaller films, including Fool for Love and Nadine. In 1991, Basinger was cast opposite Alec Baldwin in the comedy The Marrying Man, and the two hit it off -- so much so that some accused their romance of interfering with the production. The couple rode out the negative publicity, however, and married in 1993. (It was Basinger's second marriage after divorcing Ron Britton in 1989.)