Recognizing that Mullally has the gift of making people laugh, she was cast in "Stealing Harvard" (2002) a comedy about a man who turns to a life of crime to finance his niece's college education. After costarring in “Rebound” (2006), a well-intentioned Martin Lawrence comedy vehicle, Mullally—along with Debra Messing, Eric McCormack and Sean Hayes—said a tearful goodbye to “Will & Grace” with the series finale airing in 2006. Mullally earned her second Emmy for her performance as Karen, taking the award for Outstanding Supporting Actress in a Comedy Series. With the last episode of "Will & Grace" come and gone, Mullally moved on to the daytime talk show circuit with her nationally syndicated program, “The Megan Mullally Show” (NBC, 2006- ). The show premiered in September 2006 and featured a mix of talk, variety, celebrity interviews, music and comedy. For Mullally, the adjustment from the comfort of “Will & Grace” was difficult, but challenging—she worked hard in preparing for the grind of putting together an hour-long show five days a week and developed a show around elements she liked from other talk shows, including David Letterman, Jay Leno and Jon Stewart.